Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 806344..807037 Replicon chromosome
Accession NZ_OX352324
Organism Pseudomonas sp. MM221

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag OM991_RS03690 Protein ID WP_003151133.1
Coordinates 806660..807037 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag OM991_RS03685 Protein ID WP_001172026.1
Coordinates 806344..806679 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM991_RS03655 802663..802908 - 246 Protein_698 DUF4113 domain-containing protein -
OM991_RS03660 803142..803597 + 456 WP_023660738.1 glyoxalase superfamily protein -
OM991_RS03665 (GLGCALEP_00757) 803870..804739 - 870 WP_223198360.1 HD-GYP domain-containing protein -
OM991_RS31375 804823..805110 - 288 WP_269841825.1 DUF3391 domain-containing protein -
OM991_RS03670 (GLGCALEP_00758) 805267..805647 - 381 WP_001054412.1 hypothetical protein -
OM991_RS03675 (GLGCALEP_00759) 805644..805970 - 327 WP_000091614.1 hypothetical protein -
OM991_RS03680 (GLGCALEP_00760) 805994..806329 - 336 WP_000741275.1 hypothetical protein -
OM991_RS03685 (GLGCALEP_00761) 806344..806679 - 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
OM991_RS03690 (GLGCALEP_00762) 806660..807037 - 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM991_RS03695 (GLGCALEP_00763) 807229..807831 + 603 WP_010465829.1 recombinase family protein -
OM991_RS03700 807815..810889 + 3075 Protein_708 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 773376..866581 93205


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T296634 WP_003151133.1 NZ_OX352324:c807037-806660 [Pseudomonas sp. MM221]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT296634 WP_001172026.1 NZ_OX352324:c806679-806344 [Pseudomonas sp. MM221]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References