Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5783767..5784392 Replicon chromosome
Accession NZ_OX352322
Organism Pseudomonas sp. MM223

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag ONI07_RS26935 Protein ID WP_264360793.1
Coordinates 5784165..5784392 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ONI07_RS26930 Protein ID WP_264360792.1
Coordinates 5783767..5784168 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONI07_RS26910 (DBADOPDK_05493) 5780322..5781758 + 1437 WP_264360789.1 dual specificity protein phosphatase family protein -
ONI07_RS26915 (DBADOPDK_05494) 5781755..5782186 + 432 WP_264360790.1 hypothetical protein -
ONI07_RS26920 (DBADOPDK_05495) 5782197..5782820 + 624 WP_016497906.1 lysophospholipid acyltransferase family protein -
ONI07_RS26925 (DBADOPDK_05496) 5782822..5783754 + 933 WP_264360791.1 phosphatidate cytidylyltransferase -
ONI07_RS26930 (DBADOPDK_05497) 5783767..5784168 - 402 WP_264360792.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ONI07_RS26935 (DBADOPDK_05498) 5784165..5784392 - 228 WP_264360793.1 type II toxin-antitoxin system HicA family toxin Toxin
ONI07_RS26940 (DBADOPDK_05499) 5784593..5784868 - 276 WP_264360794.1 metal/formaldehyde-sensitive transcriptional repressor -
ONI07_RS26945 (DBADOPDK_05500) 5784939..5785874 + 936 WP_264360795.1 CDF family Co(II)/Ni(II) efflux transporter DmeF -
ONI07_RS26950 (DBADOPDK_05501) 5785971..5786315 + 345 WP_003258412.1 cupin domain-containing protein -
ONI07_RS26955 (DBADOPDK_05502) 5786547..5787434 - 888 WP_264360796.1 3-hydroxyisobutyrate dehydrogenase -
ONI07_RS26960 (DBADOPDK_05503) 5787444..5788970 - 1527 WP_264360797.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8305.43 Da        Isoelectric Point: 10.8123

>T296633 WP_264360793.1 NZ_OX352322:c5784392-5784165 [Pseudomonas sp. MM223]
MRSREVIQLIEADGWYEVDVKGSHHQFRHPTKRGRVKFPHPKSELPKGTVRSILKQAGLIQTGGVASTSVNGGDQ

Download         Length: 228 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14367.15 Da        Isoelectric Point: 4.4915

>AT296633 WP_264360792.1 NZ_OX352322:c5784168-5783767 [Pseudomonas sp. MM223]
MKFPVVLHKDEGSEYGVTVPDVPGCFSAGATVASALDNVQEALALHFEGLVADNEALPQATEIDAHVANPDYEGGVWAVV
DFDVTPYLGKAVRFNATLPENLLQRIDEKVKRDHRYASRSGFLASAAIRELAL

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References