296631

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 5374310..5374938 Replicon chromosome
Accession NZ_OX352322
Organism Pseudomonas sp. MM223

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag ONI07_RS25020 Protein ID WP_234229625.1
Coordinates 5374756..5374938 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ONI07_RS25015 Protein ID WP_264363461.1
Coordinates 5374310..5374732 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONI07_RS25000 (DBADOPDK_05103) 5369500..5370213 - 714 WP_264360528.1 serine O-acetyltransferase -
ONI07_RS25005 (DBADOPDK_05104) 5370386..5371726 + 1341 WP_264360529.1 PLP-dependent aminotransferase family protein -
ONI07_RS25010 (DBADOPDK_05105) 5371830..5374271 + 2442 WP_264360530.1 penicillin acylase family protein -
ONI07_RS25015 (DBADOPDK_05106) 5374310..5374732 - 423 WP_264363461.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ONI07_RS25020 (DBADOPDK_05107) 5374756..5374938 - 183 WP_234229625.1 type II toxin-antitoxin system HicA family toxin Toxin
ONI07_RS25025 (DBADOPDK_05108) 5375146..5376162 + 1017 WP_264360531.1 ligase-associated DNA damage response exonuclease -
ONI07_RS25030 (DBADOPDK_05109) 5376159..5377817 + 1659 WP_264360532.1 ATP-dependent DNA ligase -
ONI07_RS25035 (DBADOPDK_05110) 5377978..5379093 + 1116 WP_264387184.1 M14 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6851.00 Da        Isoelectric Point: 11.0323

>T296631 WP_234229625.1 NZ_OX352322:c5374938-5374756 [Pseudomonas sp. MM223]
MKYSEFRRWLRGQGATFVAAKGSHFKVYLGNRQTIFPDHGAKEISEGLRKKILKDLGLKA

Download         Length: 183 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15320.57 Da        Isoelectric Point: 4.9323

>AT296631 WP_264363461.1 NZ_OX352322:c5374732-5374310 [Pseudomonas sp. MM223]
IFEYPVVVHQEDGSVWVSCPDVPEMACAGDTSEEALFDAVDALESALSFYVDQKHAIPLPSAPTEGHPVVRLPALTAAKA
ALWNTMVAQKISKTEMARRLGVNRPQVDRLVDLLHRSKIEQVEHALNVLGQRIELSVVAV

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References