Detailed information of TA system TA029663

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 3999491..4000017
• Replicon: chromosome
• Accession: NC_021715
• Organism: Mycobacterium yongonense 05-1390

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: S4ZDZ6
• Locus tag: OEM_RS18105
• Protein ID: WP_008259048.1
• Coordinates: 3999715..4000017 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: S4ZFD0
• Locus tag: OEM_RS18100
• Protein ID: WP_008259047.1
• Coordinates: 3999491..3999718 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OEM_RS18075	3994568..3995488	-	921	WP_008259041.1	MinD/ParA family protein	-
OEM_RS18080	3995733..3996764	-	1032	WP_008259042.1	6-phosphofructokinase	-
OEM_RS18085	3996808..3998301	-	1494	WP_008259043.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	-
OEM_RS18090	3998298..3998597	-	300	WP_009952003.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
OEM_RS18095	3998697..3999353	+	657	WP_085977602.1	amino acid-binding protein	-
OEM_RS18100	3999491..3999718	+	228	WP_008259047.1	ribbon-helix-helix protein, CopG family	Antitoxin
OEM_RS18105	3999715..4000017	+	303	WP_008259048.1	hypothetical protein	Toxin
OEM_RS18110	4000133..4000441	-	309	WP_008259049.1	hypothetical protein	-
OEM_RS18115	4000500..4003421	-	2922	WP_020823252.1	MMPL family transporter	-
OEM_RS18120	4003418..4003864	-	447	WP_193375010.1	transport acessory protein MmpS	-
OEM_RS18125	4004069..4004587	+	519	WP_020823253.1	pyridoxamine 5'-phosphate oxidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10473.31 Da
• Isoelectric Point: 4.5636

>T29663 WP_008259048.1 NC_021715:3999715-4000017 [Mycobacterium intracellulare subsp. yongonense 05-1390]
MIAPGDIAPRRDTRRDLYVAVLSNAIHLAANTGRVIVCPFIPGKIPDDTMAMVVPLTQPEGTLLPELVQWLPTSALGEPI
GAVSAAALSEAMSIVTALIT

Nucleotide

• Length: 303 bp

>T29663 NC_021715:3999715-4000017 [Mycobacterium intracellulare subsp. yongonense 05-1390]
ATGATCGCGCCGGGCGACATCGCGCCGCGGCGAGACACCCGCCGCGACCTCTACGTCGCGGTGCTCTCCAACGCGATCCA
CCTCGCGGCCAACACTGGTCGCGTCATCGTCTGCCCGTTCATCCCTGGGAAAATCCCCGACGACACGATGGCCATGGTCG
TTCCGCTCACGCAGCCCGAAGGCACTCTTCTCCCCGAACTGGTGCAGTGGCTGCCGACTTCGGCGCTCGGTGAACCGATC
GGGGCCGTGTCGGCGGCCGCGCTTAGCGAGGCGATGTCGATCGTGACCGCGCTGATCACGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8173.14 Da
• Isoelectric Point: 6.4608

>AT29663 WP_008259047.1 NC_021715:3999491-3999718 [Mycobacterium intracellulare subsp. yongonense 05-1390]
MAKEKISVTVDAAVLADADSDAKAAGLNRSEMIERALRNEHLRRALHTYTTRTAPALNIDSYAGQVYEANRAADL

Nucleotide

• Length: 228 bp

>AT29663 NC_021715:3999491-3999718 [Mycobacterium intracellulare subsp. yongonense 05-1390]
ATGGCCAAAGAGAAGATTTCTGTCACCGTCGACGCCGCCGTGCTCGCCGACGCCGACTCCGACGCCAAAGCGGCCGGACT
GAATCGCTCCGAGATGATCGAGCGGGCGCTGCGCAATGAGCATCTACGTCGCGCGCTTCATACCTATACGACGCGGACCG
CACCAGCGCTCAACATCGACTCCTACGCCGGGCAAGTGTATGAAGCCAACCGGGCCGCGGACCTATGA

Structures

Toxin

• AlphaFold DB: S4ZDZ6

Antitoxin

• AlphaFold DB: S4ZFD0