296625

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 806532..807225 Replicon chromosome
Accession NZ_OX352322
Organism Pseudomonas sp. MM223

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag ONI07_RS03680 Protein ID WP_003151133.1
Coordinates 806848..807225 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag ONI07_RS03675 Protein ID WP_001172026.1
Coordinates 806532..806867 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONI07_RS03645 802851..803096 - 246 Protein_697 DUF4113 domain-containing protein -
ONI07_RS03650 803330..803785 + 456 WP_023660738.1 glyoxalase superfamily protein -
ONI07_RS03655 (DBADOPDK_00744) 804058..805337 - 1280 Protein_699 HD-GYP domain-containing protein -
ONI07_RS03660 (DBADOPDK_00745) 805455..805835 - 381 WP_001054412.1 hypothetical protein -
ONI07_RS03665 (DBADOPDK_00746) 805832..806158 - 327 WP_000091614.1 hypothetical protein -
ONI07_RS03670 (DBADOPDK_00747) 806182..806517 - 336 WP_000741275.1 hypothetical protein -
ONI07_RS03675 (DBADOPDK_00748) 806532..806867 - 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
ONI07_RS03680 (DBADOPDK_00749) 806848..807225 - 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ONI07_RS03685 (DBADOPDK_00750) 807417..808019 + 603 WP_010465829.1 recombinase family protein -
ONI07_RS03690 (DBADOPDK_00752) 808003..811033 + 3031 Protein_706 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 773552..866795 93243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T296625 WP_003151133.1 NZ_OX352322:c807225-806848 [Pseudomonas sp. MM223]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT296625 WP_001172026.1 NZ_OX352322:c806867-806532 [Pseudomonas sp. MM223]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References