Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2188471..2189124 Replicon chromosome
Accession NZ_OX352320
Organism Rheinheimera sp. MM224

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OM978_RS10335 Protein ID WP_264346805.1
Coordinates 2188471..2188650 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OM978_RS10340 Protein ID WP_264346806.1
Coordinates 2188705..2189124 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM978_RS10320 (JAMGFMIE_02075) 2184530..2185945 + 1416 WP_264346802.1 glucuronate isomerase -
OM978_RS10325 (JAMGFMIE_02076) 2185957..2187519 + 1563 WP_264346803.1 mannitol dehydrogenase family protein -
OM978_RS10330 (JAMGFMIE_02077) 2187516..2188316 + 801 WP_264346804.1 ThuA domain-containing protein -
OM978_RS10335 (JAMGFMIE_02078) 2188471..2188650 + 180 WP_264346805.1 type II toxin-antitoxin system HicA family toxin Toxin
OM978_RS10340 (JAMGFMIE_02079) 2188705..2189124 + 420 WP_264346806.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OM978_RS10345 (JAMGFMIE_02080) 2189230..2190357 - 1128 WP_264346807.1 alpha/beta hydrolase -
OM978_RS10350 (JAMGFMIE_02081) 2190376..2190753 - 378 WP_264346808.1 cyclophilin-like fold protein -
OM978_RS10355 (JAMGFMIE_02082) 2190863..2192086 - 1224 WP_264346809.1 MFS transporter -
OM978_RS10360 (JAMGFMIE_02083) 2192206..2193126 + 921 WP_264346810.1 LysR family transcriptional regulator -
OM978_RS10365 (JAMGFMIE_02084) 2193730..2194089 - 360 WP_264346811.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6583.84 Da        Isoelectric Point: 11.0850

>T296623 WP_264346805.1 NZ_OX352320:2188471-2188650 [Rheinheimera sp. MM224]
MKSSDLIKELEQAGWVLVRVKGSHHQFKHPLHKLPVTVPHPKKDLGTGLVKAIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15393.54 Da        Isoelectric Point: 4.6384

>AT296623 WP_264346806.1 NZ_OX352320:2188705-2189124 [Rheinheimera sp. MM224]
MLYPVAIEKGSEHSAFGVVVPDVPGCFSAGDTFEEALINAKEALELHLQGLAEMEELPPLASSIDHHFASPEFNGWVWAL
VDIDIEPYMGKASKINVTLPNLLTKKIDDLVQSNPMYKSRSHFLQVAAAHEFERGMQRT

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References