Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
Location | 1276469..1277124 | Replicon | chromosome |
Accession | NZ_OX352319 | ||
Organism | Pseudomonas sp. MM227 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | ONG87_RS05795 | Protein ID | WP_264382397.1 |
Coordinates | 1276942..1277124 (-) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | ONG87_RS05790 | Protein ID | WP_264382396.1 |
Coordinates | 1276469..1276891 (-) | Length | 141 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ONG87_RS05750 (AHFPHNDE_01147) | 1272161..1272850 | + | 690 | WP_264382828.1 | replication protein P | - |
ONG87_RS05755 (AHFPHNDE_01148) | 1272847..1272975 | + | 129 | WP_264382390.1 | hypothetical protein | - |
ONG87_RS05760 (AHFPHNDE_01149) | 1272981..1273286 | + | 306 | WP_264382829.1 | DUF1364 domain-containing protein | - |
ONG87_RS05765 (AHFPHNDE_01150) | 1273286..1273606 | + | 321 | WP_264382391.1 | hypothetical protein | - |
ONG87_RS05770 (AHFPHNDE_01151) | 1273603..1274034 | + | 432 | WP_264382392.1 | VRR-NUC domain-containing protein | - |
ONG87_RS05775 (AHFPHNDE_01152) | 1274031..1275332 | + | 1302 | WP_264382393.1 | site-specific integrase | - |
ONG87_RS05780 (AHFPHNDE_01153) | 1275329..1275649 | + | 321 | WP_264382394.1 | hypothetical protein | - |
ONG87_RS05785 (AHFPHNDE_01154) | 1275679..1276356 | + | 678 | WP_264382395.1 | hypothetical protein | - |
ONG87_RS05790 (AHFPHNDE_01155) | 1276469..1276891 | - | 423 | WP_264382396.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
ONG87_RS05795 (AHFPHNDE_01156) | 1276942..1277124 | - | 183 | WP_264382397.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
ONG87_RS05800 (AHFPHNDE_01157) | 1277555..1277926 | + | 372 | WP_264382398.1 | chemotaxis protein | - |
ONG87_RS05805 (AHFPHNDE_01158) | 1277926..1278264 | + | 339 | WP_264382399.1 | hypothetical protein | - |
ONG87_RS05810 (AHFPHNDE_01159) | 1278283..1279008 | + | 726 | WP_264382400.1 | hypothetical protein | - |
ONG87_RS05815 (AHFPHNDE_01160) | 1279295..1279822 | + | 528 | WP_264382401.1 | terminase small subunit | - |
ONG87_RS05820 (AHFPHNDE_01161) | 1279794..1281701 | + | 1908 | WP_264382402.1 | phage terminase large subunit family protein | - |
ONG87_RS05825 (AHFPHNDE_01162) | 1281707..1281916 | + | 210 | WP_264382403.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1258374..1314682 | 56308 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6915.10 Da Isoelectric Point: 10.5498
>T296617 WP_264382397.1 NZ_OX352319:c1277124-1276942 [Pseudomonas sp. MM227]
MSCNEFKRWLLAQGVEISKQRSKHFKIFYNGKQTVLPDHGAKEIGEGLRKTIIKQLGLKD
MSCNEFKRWLLAQGVEISKQRSKHFKIFYNGKQTVLPDHGAKEIGEGLRKTIIKQLGLKD
Download Length: 183 bp
Antitoxin
Download Length: 141 a.a. Molecular weight: 15235.45 Da Isoelectric Point: 5.6306
>AT296617 WP_264382396.1 NZ_OX352319:c1276891-1276469 [Pseudomonas sp. MM227]
MFSYAIKVHAEAGSFWSSCRDIPEAHSAGDTEEELLANAVEGLELALTIYVDQSRPIPLPSAPVKGERVVHLPTLLAAKV
SLWNAMREANMRKADLARLLQSSQTKVDRLLDFEHSSKIEQVEAALAALGKRLAVSVEAA
MFSYAIKVHAEAGSFWSSCRDIPEAHSAGDTEEELLANAVEGLELALTIYVDQSRPIPLPSAPVKGERVVHLPTLLAAKV
SLWNAMREANMRKADLARLLQSSQTKVDRLLDFEHSSKIEQVEAALAALGKRLAVSVEAA
Download Length: 423 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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