Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 417273..417937 Replicon chromosome
Accession NZ_OX352319
Organism Pseudomonas sp. MM227

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ONG87_RS01870 Protein ID WP_192055813.1
Coordinates 417533..417937 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ONG87_RS01865 Protein ID WP_185794949.1
Coordinates 417273..417536 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONG87_RS01840 (AHFPHNDE_00365) 412408..413265 + 858 WP_185794946.1 formyltetrahydrofolate deformylase -
ONG87_RS01845 (AHFPHNDE_00366) 413466..414665 + 1200 WP_122480430.1 formaldehyde dehydrogenase, glutathione-independent -
ONG87_RS01850 (AHFPHNDE_00367) 415009..415581 + 573 WP_122480429.1 DUF2780 domain-containing protein -
ONG87_RS01855 (AHFPHNDE_00368) 415582..416472 - 891 WP_264382098.1 acyltransferase -
ONG87_RS01860 (AHFPHNDE_00369) 416616..417119 + 504 WP_122480427.1 ATP-dependent zinc protease -
ONG87_RS01865 (AHFPHNDE_00370) 417273..417536 + 264 WP_185794949.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ONG87_RS01870 (AHFPHNDE_00371) 417533..417937 + 405 WP_192055813.1 type II toxin-antitoxin system VapC family toxin Toxin
ONG87_RS01875 (AHFPHNDE_00372) 417951..418574 - 624 WP_240998857.1 glutathione S-transferase -
ONG87_RS01880 (AHFPHNDE_00373) 418726..420420 - 1695 WP_264382099.1 ABC transporter ATP-binding protein -
ONG87_RS01885 (AHFPHNDE_00374) 420750..420932 - 183 WP_264382892.1 hypothetical protein -
ONG87_RS01890 (AHFPHNDE_00375) 420929..422053 - 1125 WP_185794953.1 PepSY-associated TM helix domain-containing protein -
ONG87_RS01895 (AHFPHNDE_00376) 422197..422904 - 708 WP_264382100.1 3'-5' exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14275.61 Da        Isoelectric Point: 7.7481

>T296616 WP_192055813.1 NZ_OX352319:417533-417937 [Pseudomonas sp. MM227]
MKQLMLDTNTVSYLLKGHPAVIKNLSAVPMASVCISSITEAELLYGLAKRPSAQRLAGLVNAFLKTVDILPWGSQAAQAY
GSSRAVGERRGQCLGTLDGLIAAHSLSLGMTLVTSDKAFRLVEGLEVQDWCEVA

Download         Length: 405 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9622.58 Da        Isoelectric Point: 4.0886

>AT296616 WP_185794949.1 NZ_OX352319:417273-417536 [Pseudomonas sp. MM227]
MSQTAKVFVNGRSQAVRLPAAFRFDTDEVFIRRDPETGDVILSRKPDSWDEFLALVAEGGVPDDFLNADDRTQAGGENRD
PLDGIPE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References