Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2839815..2840344 Replicon chromosome
Accession NZ_OX344719
Organism Staphylococcus aureus strain ST20190863 isolate ST20190863

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OOL12_RS14320 Protein ID WP_000621175.1
Coordinates 2839982..2840344 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OOL12_RS14315 Protein ID WP_000948331.1
Coordinates 2839815..2839985 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOL12_RS14285 (2834852) 2834852..2835412 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
OOL12_RS14290 (2835620) 2835620..2836099 + 480 WP_001287088.1 hypothetical protein -
OOL12_RS14295 (2836092) 2836092..2837675 + 1584 WP_001294626.1 PH domain-containing protein -
OOL12_RS14300 (2837662) 2837662..2838153 + 492 WP_001205910.1 PH domain-containing protein -
OOL12_RS14305 (2838157) 2838157..2838516 + 360 WP_000581200.1 holo-ACP synthase -
OOL12_RS14310 (2838582) 2838582..2839730 + 1149 WP_001281145.1 alanine racemase -
OOL12_RS14315 (2839815) 2839815..2839985 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OOL12_RS14320 (2839982) 2839982..2840344 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OOL12_RS14325 (2840694) 2840694..2841695 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OOL12_RS14330 (2841814) 2841814..2842140 + 327 WP_001052491.1 anti-sigma factor antagonist -
OOL12_RS14335 (2842142) 2842142..2842621 + 480 WP_001190829.1 anti-sigma B factor RsbW -
OOL12_RS14340 (2842596) 2842596..2843366 + 771 WP_001041103.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T296612 WP_000621175.1 NZ_OX344719:2839982-2840344 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT296612 WP_000948331.1 NZ_OX344719:2839815-2839985 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References