Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2820074..2820588 Replicon chromosome
Accession NZ_OX344719
Organism Staphylococcus aureus strain ST20190863 isolate ST20190863

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag OOL12_RS14230 Protein ID WP_000581792.1
Coordinates 2820379..2820588 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OOL12_RS14225 Protein ID WP_000138932.1
Coordinates 2820074..2820367 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOL12_RS14205 (2815437) 2815437..2816078 + 642 WP_000483153.1 thiamine phosphate synthase -
OOL12_RS14210 (2816164) 2816164..2817036 + 873 WP_000725802.1 membrane protein insertase YidC -
OOL12_RS14215 (2817749) 2817749..2818396 - 648 WP_001187629.1 HD domain-containing protein -
OOL12_RS14220 (2818424) 2818424..2819908 - 1485 WP_264717377.1 cardiolipin synthase -
OOL12_RS14225 (2820074) 2820074..2820367 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OOL12_RS14230 (2820379) 2820379..2820588 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
OOL12_RS14235 (2820716) 2820716..2820853 + 138 WP_000828354.1 Lmo0850 family protein -
OOL12_RS14240 (2821117) 2821117..2822319 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OOL12_RS14245 (2822637) 2822637..2823707 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
OOL12_RS14250 (2823722) 2823722..2825080 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T296611 WP_000581792.1 NZ_OX344719:2820379-2820588 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT296611 WP_000138932.1 NZ_OX344719:2820074-2820367 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References