Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 122015..122791 Replicon chromosome
Accession NZ_OX344719
Organism Staphylococcus aureus strain ST20190863 isolate ST20190863

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OOL12_RS00785 Protein ID WP_000031108.1
Coordinates 122639..122791 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag OOL12_RS00780 Protein ID WP_001251224.1
Coordinates 122015..122614 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOL12_RS00760 (117931) 117931..119388 + 1458 WP_000649907.1 ABC transporter permease subunit -
OOL12_RS00765 (119381) 119381..120103 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OOL12_RS00770 (120254) 120254..121381 + 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
OOL12_RS00775 (121386) 121386..121856 + 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OOL12_RS00780 (122015) 122015..122614 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
OOL12_RS00785 (122639) 122639..122791 + 153 WP_000031108.1 SAS053 family protein Toxin
OOL12_RS00790 (123568) 123568..123963 + 396 WP_000901021.1 hypothetical protein -
OOL12_RS00795 (124159) 124159..125544 + 1386 WP_000116224.1 class II fumarate hydratase -
OOL12_RS00800 (126007) 126007..126828 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T296600 WP_000031108.1 NZ_OX344719:122639-122791 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT296600 WP_001251224.1 NZ_OX344719:122015-122614 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References