Detailed information of TA system TA029660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1143868..1144412
• Replicon: chromosome
• Accession: NC_021715
• Organism: Mycobacterium yongonense 05-1390

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OEM_RS05640
• Protein ID: WP_041321307.1
• Coordinates: 1144167..1144412 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S4Z4W6
• Locus tag: OEM_RS05635
• Protein ID: WP_020821851.1
• Coordinates: 1143868..1144152 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OEM_RS05610	1138944..1139543	-	600	WP_009953444.1	lipid droplet-associated protein	-
OEM_RS05615	1139633..1140631	+	999	WP_008254378.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
OEM_RS05620	1140677..1141822	-	1146	WP_201767262.1	hypothetical protein	-
OEM_RS05625	1141952..1143025	+	1074	WP_020821849.1	redox-regulated ATPase YchF	-
OEM_RS05630	1143042..1143782	+	741	WP_020821850.1	aminoglycoside 3'-phosphotransferase	-
OEM_RS05635	1143868..1144152	+	285	WP_020821851.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OEM_RS05640	1144167..1144412	+	246	WP_041321307.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OEM_RS05645	1144448..1144999	+	552	WP_020821853.1	VOC family protein	-
OEM_RS05650	1145078..1145476	+	399	WP_020821854.1	VOC family protein	-
OEM_RS05655	1145571..1145768	+	198	WP_036455532.1	type II toxin-antitoxin system VapB family antitoxin	-
OEM_RS05660	1145765..1146133	+	369	WP_020821856.1	type II toxin-antitoxin system VapC family toxin	-
OEM_RS05665	1146316..1146657	+	342	WP_020821857.1	hypothetical protein	-
OEM_RS27885	1146743..1147102	+	360	WP_201767263.1	hypothetical protein	-
OEM_RS05675	1147286..1147861	+	576	WP_075630262.1	C40 family peptidase	-
OEM_RS05680	1148224..1148547	+	324	WP_020821860.1	antibiotic biosynthesis monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (29-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9375.93 Da
• Isoelectric Point: 11.0314

>T29660 WP_041321307.1 NC_021715:1144167-1144412 [Mycobacterium intracellulare subsp. yongonense 05-1390]
MTAAAKKALTDLLPESVAVACWEFIRGPLAENPQRVGKPLRGQLEGRYSARRGEFRVIYRIFDERVVVRVIHIAHRRDVY
R

Nucleotide

• Length: 246 bp

>T29660 NC_021715:1144167-1144412 [Mycobacterium intracellulare subsp. yongonense 05-1390]
ATGACAGCGGCCGCCAAGAAAGCGCTCACCGATCTGCTGCCCGAGTCAGTGGCCGTTGCTTGCTGGGAGTTCATTCGGGG
TCCGCTCGCGGAGAACCCGCAGCGGGTGGGCAAGCCGCTTCGCGGCCAGTTGGAAGGGCGATACTCGGCGCGCAGGGGCG
AGTTTCGCGTCATTTACCGGATCTTCGACGAACGGGTGGTGGTCCGCGTCATCCACATCGCGCATCGCCGCGACGTTTAC
CGGTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10513.88 Da
• Isoelectric Point: 4.3705

>AT29660 WP_020821851.1 NC_021715:1143868-1144152 [Mycobacterium intracellulare subsp. yongonense 05-1390]
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQDLMREVRAAESEAEDGALYTLD
QVTEEMRAVGRLPR

Nucleotide

• Length: 285 bp

>AT29660 NC_021715:1143868-1144152 [Mycobacterium intracellulare subsp. yongonense 05-1390]
ATGTCGACGCTTCCGCTGGCCGAGGTCCGAGCCAACCTTTCCAAGCTGGTCGACGAGGCCGTCCGGACCCATGAGCGCAT
CGAGGTCACCAGGCAAGGTCGCCGGGCGGCGGTGATTCTCAGCGCGGATGACTTCGATTCGATTATGGAAACTCTGGCCA
TCCTCAGCGATCAGGACTTGATGCGCGAAGTCCGAGCGGCAGAGTCAGAGGCAGAGGACGGCGCGCTCTACACACTCGAT
CAGGTGACCGAGGAGATGCGTGCTGTCGGCCGGCTCCCGCGGTGA

Structures

Antitoxin

• AlphaFold DB: S4Z4W6