Detailed information of TA system TA296594

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5011922..5013603
• Replicon: chromosome
• Accession: NZ_OX337252
• Organism: Klebsiella pneumoniae isolate 65326252-51f1-11ec-980a-fa163eea3084

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: OGZ45_RS24385
• Protein ID: WP_087834431.1
• Coordinates: 5011922..5012839 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: OGZ45_RS24390
• Protein ID: WP_004177809.1
• Coordinates: 5012845..5013603 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OGZ45_RS24365	5007228..5008748	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
OGZ45_RS24370	5008745..5009743	+	999	WP_004186549.1	ribose ABC transporter permease	-
OGZ45_RS24375	5009774..5010715	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
OGZ45_RS24380	5010790..5011797	+	1008	WP_004177805.1	carbohydrate kinase family protein	-
OGZ45_RS24385	5011922..5012839	-	918	WP_087834431.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
OGZ45_RS24390	5012845..5013603	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
OGZ45_RS24395	5013689..5014417	-	729	WP_002885152.1	response regulator transcription factor	-
OGZ45_RS24400	5014690..5016837	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
OGZ45_RS24405	5016834..5016977	-	144	WP_022631365.1	hypothetical protein	-
OGZ45_RS24410	5017525..5018211	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34532.94 Da
• Isoelectric Point: 5.2461

>T296594 WP_087834431.1 NZ_OX337252:c5012839-5011922 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEGEVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT296594 WP_004177809.1 NZ_OX337252:c5013603-5012845 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05