Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4842560..4843076 Replicon chromosome
Accession NZ_OX337252
Organism Klebsiella pneumoniae isolate 65326252-51f1-11ec-980a-fa163eea3084

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OGZ45_RS23535 Protein ID WP_004178374.1
Coordinates 4842560..4842844 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OGZ45_RS23540 Protein ID WP_002886901.1
Coordinates 4842834..4843076 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGZ45_RS23510 4837977..4838285 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
OGZ45_RS23515 4838370..4838543 + 174 WP_032408826.1 hypothetical protein -
OGZ45_RS23520 4838546..4839289 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OGZ45_RS23525 4839646..4841784 + 2139 WP_087834662.1 anaerobic ribonucleoside-triphosphate reductase -
OGZ45_RS23530 4842092..4842556 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OGZ45_RS23535 4842560..4842844 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OGZ45_RS23540 4842834..4843076 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OGZ45_RS23545 4843154..4845064 - 1911 WP_040225314.1 PRD domain-containing protein -
OGZ45_RS23550 4845087..4846241 - 1155 WP_049000495.1 lactonase family protein -
OGZ45_RS23555 4846308..4847048 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T296593 WP_004178374.1 NZ_OX337252:c4842844-4842560 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT296593 WP_002886901.1 NZ_OX337252:c4843076-4842834 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References