Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4678866..4679676 Replicon chromosome
Accession NZ_OX337252
Organism Klebsiella pneumoniae isolate 65326252-51f1-11ec-980a-fa163eea3084

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag OGZ45_RS22825 Protein ID WP_004178461.1
Coordinates 4678866..4679399 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag OGZ45_RS22830 Protein ID WP_002887278.1
Coordinates 4679410..4679676 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGZ45_RS22820 4677697..4678818 + 1122 WP_009309849.1 cupin domain-containing protein -
OGZ45_RS22825 4678866..4679399 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
OGZ45_RS22830 4679410..4679676 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
OGZ45_RS22835 4679779..4681212 - 1434 WP_004894565.1 Cu(+)/Ag(+) sensor histidine kinase -
OGZ45_RS22840 4681202..4681885 - 684 WP_087834849.1 copper response regulator transcription factor CusR -
OGZ45_RS22845 4682057..4683442 + 1386 WP_087834848.1 efflux transporter outer membrane subunit -
OGZ45_RS22850 4683460..4683804 + 345 WP_015959364.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T296592 WP_004178461.1 NZ_OX337252:c4679399-4678866 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT296592 WP_002887278.1 NZ_OX337252:c4679676-4679410 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References