Detailed information of TA system TA029659

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 889848..890501
• Replicon: chromosome
• Accession: NC_021715
• Organism: Mycobacterium yongonense 05-1390

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: OEM_RS04480
• Protein ID: WP_008253911.1
• Coordinates: 890040..890501 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: S4Z3M5
• Locus tag: OEM_RS04475
• Protein ID: WP_020821688.1
• Coordinates: 889848..890036 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OEM_RS04465	885822..887399	+	1578	WP_020821686.1	serine hydrolase	-
OEM_RS04470	887396..889783	+	2388	WP_020821687.1	cation-translocating P-type ATPase	-
OEM_RS04475	889848..890036	+	189	WP_020821688.1	antitoxin	Antitoxin
OEM_RS04480	890040..890501	+	462	WP_008253911.1	SRPBCC family protein	Toxin
OEM_RS04485	890586..891356	+	771	WP_020821689.1	VOC family protein	-
OEM_RS04490	891430..891864	+	435	WP_041320814.1	hypothetical protein	-
OEM_RS04495	891869..892357	-	489	WP_036454690.1	glyoxalase/bleomycin resistance/dioxygenase family protein	-
OEM_RS04500	892357..893871	-	1515	WP_020821692.1	carotenoid oxygenase family protein	-
OEM_RS04505	893874..895094	-	1221	WP_020821693.1	acetyl-CoA acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-52)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 16639.20 Da
• Isoelectric Point: 8.5617

>T29659 WP_008253911.1 NC_021715:890040-890501 [Mycobacterium intracellulare subsp. yongonense 05-1390]
MAKLSGSIDVPLPPEVAWQHASDLSRYKDWLTIHRVWRSALPDEIEKGSVVESIVEVKGMPNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKIQPKGDGSLVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFTRPDPSSNGHR

Nucleotide

• Length: 462 bp

>T29659 NC_021715:890040-890501 [Mycobacterium intracellulare subsp. yongonense 05-1390]
ATGGCCAAGCTTTCCGGATCCATCGATGTCCCGCTGCCGCCCGAGGTGGCTTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGATTGGCTGACTATCCACCGGGTGTGGCGCAGCGCATTGCCCGACGAGATCGAGAAAGGCTCGGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCCCAACCGGATCAAATGGACGGTCGTGCGCTACAAGCCACCCGAGGGCATGACGCTCAAC
GGCGACGGAGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGATCCAGCCCAAAGGGGACGGCTCCCTCGTCAGCTTCGA
CGTGCACCTCGGTGGCCCCGCACTGTTCGGTCCCATCGGCATGATCGTCGCCGCCGCACTGCGCGGCGATATCGACCAGT
CGCTGGAGAACTTCGTGACGGTGTTCACCCGGCCCGATCCGAGCAGCAACGGGCATCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6726.36 Da
• Isoelectric Point: 4.4702

>AT29659 WP_020821688.1 NC_021715:889848-890036 [Mycobacterium intracellulare subsp. yongonense 05-1390]
MGFLDKAKDLLSQNADKVETAIDKAGEFVDEKTQGKYSDTIHQVQEQVKKAAGAADTGDQQN

Nucleotide

• Length: 189 bp

>AT29659 NC_021715:889848-890036 [Mycobacterium intracellulare subsp. yongonense 05-1390]
ATGGGATTCCTGGACAAGGCCAAGGATCTATTGTCGCAGAACGCCGACAAGGTCGAGACGGCCATCGACAAGGCAGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAATACTCCGACACCATTCACCAGGTGCAGGAGCAGGTGAAGAAGGCGGCCGGCG
CCGCGGACACGGGCGACCAGCAGAACTGA

Structures

Antitoxin

• AlphaFold DB: S4Z3M5