Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2775025..2776613 Replicon chromosome
Accession NZ_OX337252
Organism Klebsiella pneumoniae isolate 65326252-51f1-11ec-980a-fa163eea3084

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OGZ45_RS13690 Protein ID WP_087834312.1
Coordinates 2775025..2776347 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OGZ45_RS13695 Protein ID WP_004176198.1
Coordinates 2776347..2776613 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGZ45_RS13675 2770081..2772582 + 2502 WP_087834310.1 fimbria/pilus outer membrane usher protein -
OGZ45_RS13680 2772570..2773574 + 1005 WP_087834311.1 fimbrial protein -
OGZ45_RS13685 2773716..2775008 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OGZ45_RS13690 2775025..2776347 - 1323 WP_087834312.1 type II toxin-antitoxin system HipA family toxin Toxin
OGZ45_RS13695 2776347..2776613 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OGZ45_RS13700 2776999..2777325 - 327 WP_002904788.1 hydroxyisourate hydrolase -
OGZ45_RS13705 2777322..2777822 - 501 WP_038431649.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OGZ45_RS13710 2777800..2779179 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
OGZ45_RS13715 2779525..2780679 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OGZ45_RS13720 2780660..2781583 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49143.47 Da        Isoelectric Point: 7.5357

>T296589 WP_087834312.1 NZ_OX337252:c2776347-2775025 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESMDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT296589 WP_004176198.1 NZ_OX337252:c2776613-2776347 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References