Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2323536..2324165 Replicon chromosome
Accession NZ_OX336253
Organism Neisseria sp. Marseille-Q5346

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OGY80_RS11360 Protein ID WP_009174526.1
Coordinates 2323989..2324165 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OGY80_RS11355 Protein ID WP_107842571.1
Coordinates 2323536..2323952 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGY80_RS11340 2318622..2319059 - 438 WP_003757627.1 hypothetical protein -
OGY80_RS11345 2319177..2319818 - 642 WP_003757630.1 S24 family peptidase -
OGY80_RS11350 2320274..2323114 + 2841 WP_263341725.1 DUF5906 domain-containing protein -
OGY80_RS11355 2323536..2323952 - 417 WP_107842571.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OGY80_RS11360 2323989..2324165 - 177 WP_009174526.1 type II toxin-antitoxin system HicA family toxin Toxin
OGY80_RS11365 2324312..2325064 - 753 WP_263341732.1 hypothetical protein -
OGY80_RS11370 2325393..2326358 + 966 WP_263341734.1 Bro-N domain-containing protein -
OGY80_RS11375 2326491..2326895 + 405 WP_263341736.1 molecular chaperone DnaJ -
OGY80_RS11380 2327182..2327844 + 663 WP_263341738.1 hypothetical protein -
OGY80_RS11385 2328124..2328564 - 441 WP_049322359.1 phage virion morphogenesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2312304..2352714 40410


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6719.96 Da        Isoelectric Point: 10.7708

>T296582 WP_009174526.1 NZ_OX336253:c2324165-2323989 [Neisseria sp. Marseille-Q5346]
MKQSEFLKWLMAQGVETKDGTRHIKLYYKGKQSHLPRHPSKELKTGLVEGIKKQLGLK

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15421.57 Da        Isoelectric Point: 4.3191

>AT296582 WP_107842571.1 NZ_OX336253:c2323952-2323536 [Neisseria sp. Marseille-Q5346]
MYYPAKFTPAEEGGYVVTFRDIPEAITQGDDMTEAVEMAEDVLQSAMDFYFEDQRPAPLPSAPEEGERLVALPLSVYSKV
LLLNEMLAQDVSKSELARRLETTPQEVQRITGLHHATKIDTVVRALAQLGKQLEIRLA

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References