Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 16427..17016 Replicon chromosome
Accession NZ_OX336137
Organism Nitrospina watsonii strain 347 isolate Nitrospina watsonii

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QML71_RS00100 Protein ID WP_282009859.1
Coordinates 16427..16819 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QML71_RS00105 Protein ID WP_282009860.1
Coordinates 16816..17016 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QML71_RS00055 (NSPWAT_0009) 11530..12114 + 585 WP_282009855.1 hypothetical protein -
QML71_RS00080 (NSPWAT_0010) 13186..14853 + 1668 WP_282009856.1 DNA polymerase III subunit gamma/tau -
QML71_RS00085 (NSPWAT_0011) 14869..15198 + 330 WP_282009857.1 YbaB/EbfC family nucleoid-associated protein -
QML71_RS00090 (NSPWAT_0012) 15195..15803 + 609 WP_282009858.1 recombination mediator RecR -
QML71_RS00100 (NSPWAT_0013) 16427..16819 - 393 WP_282009859.1 PIN domain nuclease Toxin
QML71_RS00105 (NSPWAT_0014) 16816..17016 - 201 WP_282009860.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QML71_RS00110 (NSPWAT_0015) 17169..17795 - 627 WP_282009861.1 isochorismate family cysteine hydrolase YcaC -
QML71_RS00115 (NSPWAT_0016) 17840..18811 - 972 WP_282009862.1 ketopantoate reductase family protein -
QML71_RS00120 (NSPWAT_0017) 19107..19790 + 684 WP_282009863.1 thermonuclease family protein -
QML71_RS00125 (NSPWAT_0018) 20108..21475 + 1368 WP_282009864.1 tRNA 5-hydroxyuridine modification protein YegQ -
QML71_RS00130 (NSPWAT_0019) 21561..21758 - 198 WP_282009865.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-48)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15037.47 Da        Isoelectric Point: 6.2348

>T296580 WP_282009859.1 NZ_OX336137:c16819-16427 [Nitrospina watsonii]
MILVDTSVWVDFLKGADSRERRALRRLIEEEADLALTGIILTETLQGIREDKDFNKVKESLLAFPLCQPKDFETYLKAAQ
IYRDCRKQGKTVRKTVDCLIAAICLEHDLILFHKDRNFDHIADCTELKVL

Download         Length: 393 bp

>T296580 NZ_OX336137:c16819-16427 [Nitrospina watsonii]
ATGATTCTGGTGGACACCAGCGTCTGGGTGGATTTTCTGAAAGGTGCGGATTCCCGGGAGCGGCGCGCCCTGCGCCGGCT
CATTGAGGAAGAAGCGGATCTTGCCCTAACGGGTATCATCTTGACAGAAACCCTGCAGGGTATCCGGGAGGACAAGGACT
TTAATAAAGTAAAAGAATCCCTGCTTGCATTCCCCCTTTGCCAGCCAAAGGACTTCGAAACCTACCTGAAAGCGGCGCAG
ATTTACCGGGACTGCCGCAAGCAGGGCAAGACGGTGAGGAAGACCGTCGATTGCCTCATCGCCGCCATCTGCCTGGAACA
CGATCTCATCCTGTTTCACAAGGACCGCAACTTCGACCACATCGCTGACTGCACGGAATTGAAAGTGCTGTAG

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7971.56 Da        Isoelectric Point: 10.9867

>AT296580 WP_282009860.1 NZ_OX336137:c17016-16816 [Nitrospina watsonii]
MLRTNIELDEKLVKEAMRLTRKKTKKELVNYALEELITRRKRKKLLDLEGKVKWTGKLDEMRKGRT

Download         Length: 201 bp

>AT296580 NZ_OX336137:c17016-16816 [Nitrospina watsonii]
ATGTTACGCACCAATATCGAACTCGACGAAAAACTGGTGAAGGAAGCCATGCGGCTGACCCGCAAGAAAACGAAAAAGGA
ACTGGTGAATTACGCCCTGGAAGAACTCATCACCCGGCGCAAACGGAAAAAACTGCTCGACCTCGAAGGGAAAGTGAAAT
GGACCGGAAAGCTGGATGAGATGCGGAAAGGACGCACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References