Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 6306040..6306641 Replicon chromosome
Accession NZ_OX216966
Organism Paenibacillus dendritiformis isolate ena-SAMPLE-TAB-03-06-2022-11:19:07:959-6672

Toxin (Protein)


Gene name mazF Uniprot ID H3SFP1
Locus tag NNL35_RS28340 Protein ID WP_006676846.1
Coordinates 6306040..6306375 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NNL35_RS28345 Protein ID WP_238535330.1
Coordinates 6306372..6306641 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNL35_RS28325 (H7S4_005666) 6301855..6303147 - 1293 WP_202947080.1 citrate transporter -
NNL35_RS28330 (H7S4_005667) 6303194..6304552 - 1359 WP_006676848.1 FAD-dependent oxidoreductase -
NNL35_RS28335 (H7S4_005668) 6304771..6305448 - 678 WP_006676847.1 N-acetylmuramoyl-L-alanine amidase -
NNL35_RS28340 (H7S4_005669) 6306040..6306375 - 336 WP_006676846.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NNL35_RS28345 (H7S4_005670) 6306372..6306641 - 270 WP_238535330.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NNL35_RS28350 (H7S4_005671) 6307129..6308619 + 1491 WP_006676844.1 peptide MFS transporter -
NNL35_RS28355 (H7S4_005672) 6309297..6311351 + 2055 WP_006676843.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12237.12 Da        Isoelectric Point: 5.8184

>T296574 WP_006676846.1 NZ_OX216966:c6306375-6306040 [Paenibacillus dendritiformis]
MTVPGRGDLVWLNFDAQAGYEQAGRRPAIVLSEADFNEVTGFAVVCPITSQVTNYPFEVPLPEGFPFTGVVLTDQLKSLD
VKNRRMKIVANIHVESECMKAVLRNARSILA

Download         Length: 336 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10067.61 Da        Isoelectric Point: 5.1891

>AT296574 WP_238535330.1 NZ_OX216966:c6306641-6306372 [Paenibacillus dendritiformis]
MTTATLRKWGNSSAVRIPNQIVKRLNLEEGAEIELIVTPENDLLLRPMKKAQESNEELRAHLKLLLAKIKPDSPRHDEVD
VGIEGDEMI

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H3SFP1

Antitoxin

Source ID Structure

References