Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 6211716..6212351 Replicon chromosome
Accession NZ_OX216966
Organism Paenibacillus dendritiformis isolate ena-SAMPLE-TAB-03-06-2022-11:19:07:959-6672

Toxin (Protein)


Gene name pemK Uniprot ID H3SI32
Locus tag NNL35_RS27920 Protein ID WP_006677694.1
Coordinates 6211716..6212066 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2W4HCL7
Locus tag NNL35_RS27925 Protein ID WP_040731899.1
Coordinates 6212070..6212351 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNL35_RS27915 (H7S4_005584) 6208510..6210981 + 2472 WP_006677695.1 M60 family metallopeptidase -
NNL35_RS27920 (H7S4_005585) 6211716..6212066 - 351 WP_006677694.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NNL35_RS27925 (H7S4_005586) 6212070..6212351 - 282 WP_040731899.1 CopG family ribbon-helix-helix protein Antitoxin
NNL35_RS27930 (H7S4_005587) 6212559..6213794 - 1236 WP_006677692.1 alanine racemase -
NNL35_RS27935 (H7S4_005588) 6214036..6215154 - 1119 WP_006677691.1 DUF4367 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12843.83 Da        Isoelectric Point: 5.5664

>T296573 WP_006677694.1 NZ_OX216966:c6212066-6211716 [Paenibacillus dendritiformis]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMHKVDDGLLISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10735.45 Da        Isoelectric Point: 8.4934

>AT296573 WP_040731899.1 NZ_OX216966:c6212351-6212070 [Paenibacillus dendritiformis]
VANIQNTKRIMISLPDQLLQEVDGIVAMEKSNRSEFIRQAMKLYLQERKKRHIRESMQRGYMEMAKINLTMASEAFYAEV
EADGTLDRLVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H3SI32

Antitoxin

Source ID Structure
AlphaFold DB A0A2W4HCL7

References