296567

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 94074..94717 Replicon plasmid P1
Accession NZ_OX030729
Organism Escherichia coli isolate 68

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag LQ200_RS25845 Protein ID WP_001044768.1
Coordinates 94301..94717 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag LQ200_RS25840 Protein ID WP_001261287.1
Coordinates 94074..94304 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ200_RS25825 (89312) 89312..90949 - 1638 WP_223201785.1 hypothetical protein -
LQ200_RS25830 (91292) 91292..92520 + 1229 WP_088895425.1 IS3-like element IS2 family transposase -
LQ200_RS25835 (92445) 92445..93767 - 1323 WP_230139594.1 hypothetical protein -
LQ200_RS25840 (94074) 94074..94304 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQ200_RS25845 (94301) 94301..94717 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ200_RS25850 (94879) 94879..97017 - 2139 WP_000350635.1 AAA family ATPase -
LQ200_RS25855 (97482) 97482..98477 + 996 WP_000246636.1 hypothetical protein -
LQ200_RS25860 (98520) 98520..99413 + 894 WP_001553853.1 S-4TM family putative pore-forming effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aac(3)-IId / erm(B) / mph(A) / sul1 / qacE / aadA5 / aac(6')-Ib-cr / blaOXA-1 / catB3 / blaTEM-1B - 1..115409 115409
- flank IS/Tn - - 99550..100053 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T296567 WP_001044768.1 NZ_OX030729:94301-94717 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT296567 WP_001261287.1 NZ_OX030729:94074-94304 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References