296561

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 5209966..5210671 Replicon chromosome
Accession NZ_OX030728
Organism Escherichia coli isolate 68

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag LQ200_RS24885 Protein ID WP_000539521.1
Coordinates 5210285..5210671 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LQ200_RS24880 Protein ID WP_001280945.1
Coordinates 5209966..5210295 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ200_RS24865 (5205123) 5205123..5206034 + 912 WP_001236018.1 glutathione ABC transporter permease GsiD -
LQ200_RS24870 (5206212) 5206212..5208560 + 2349 WP_001328220.1 EAL domain-containing protein -
LQ200_RS24875 (5208568) 5208568..5209896 + 1329 WP_000086868.1 GGDEF domain-containing protein -
LQ200_RS24880 (5209966) 5209966..5210295 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
LQ200_RS24885 (5210285) 5210285..5210671 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ200_RS24890 (5210897) 5210897..5212222 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
LQ200_RS24895 (5212435) 5212435..5212818 + 384 WP_000497137.1 biofilm formation regulator BssR -
LQ200_RS24900 (5212929) 5212929..5214044 + 1116 WP_000555049.1 aldose sugar dehydrogenase YliI -
LQ200_RS24905 (5214041) 5214041..5214667 - 627 WP_001328219.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T296561 WP_000539521.1 NZ_OX030728:c5210671-5210285 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT296561 WP_001280945.1 NZ_OX030728:c5210295-5209966 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References