Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4786322..4786940 Replicon chromosome
Accession NZ_OX030728
Organism Escherichia coli isolate 68

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ200_RS23025 Protein ID WP_001291435.1
Coordinates 4786322..4786540 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ200_RS23030 Protein ID WP_000344800.1
Coordinates 4786566..4786940 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ200_RS22990 (4781611) 4781611..4782183 + 573 WP_000779831.1 YbaY family lipoprotein -
LQ200_RS22995 (4782214) 4782214..4782525 - 312 WP_000409905.1 MGMT family protein -
LQ200_RS23005 (4782904) 4782904..4783257 + 354 WP_000878140.1 DUF1428 domain-containing protein -
LQ200_RS23010 (4783299) 4783299..4784849 - 1551 WP_001445674.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ200_RS23015 (4785013) 4785013..4785483 - 471 WP_001328420.1 YlaC family protein -
LQ200_RS23020 (4785599) 4785599..4786150 - 552 WP_000102573.1 maltose O-acetyltransferase -
LQ200_RS23025 (4786322) 4786322..4786540 - 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ200_RS23030 (4786566) 4786566..4786940 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ200_RS23035 (4787486) 4787486..4790635 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
LQ200_RS23040 (4790658) 4790658..4791851 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T296560 WP_001291435.1 NZ_OX030728:c4786540-4786322 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT296560 WP_000344800.1 NZ_OX030728:c4786940-4786566 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References