Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4582970..4584659 Replicon chromosome
Accession NZ_OX030728
Organism Escherichia coli isolate 68

Toxin (Protein)


Gene name mosT Uniprot ID V0Z9M0
Locus tag LQ200_RS22085 Protein ID WP_000365809.1
Coordinates 4583739..4584659 (+) Length 307 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag LQ200_RS22080 Protein ID WP_001134469.1
Coordinates 4582970..4583752 (+) Length 261 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ200_RS22065 (4578279) 4578279..4578482 - 204 Protein_4312 integrase -
LQ200_RS22070 (4578628) 4578628..4579098 - 471 WP_000201184.1 hypothetical protein -
LQ200_RS22075 (4579445) 4579445..4582654 - 3210 WP_000222103.1 hypothetical protein -
LQ200_RS22080 (4582970) 4582970..4583752 + 783 WP_001134469.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
LQ200_RS22085 (4583739) 4583739..4584659 + 921 WP_000365809.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LQ200_RS22090 (4585093) 4585093..4585977 - 885 WP_001119037.1 LysR family transcriptional regulator -
LQ200_RS22095 (4586242) 4586242..4587300 + 1059 WP_122452191.1 alpha/beta hydrolase -
LQ200_RS22100 (4587442) 4587442..4588569 + 1128 WP_000171074.1 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 307 a.a.        Molecular weight: 34571.01 Da        Isoelectric Point: 7.2649

>T296559 WP_000365809.1 NZ_OX030728:4583739-4584659 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Download         Length: 921 bp


Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29146.44 Da        Isoelectric Point: 8.9059

>AT296559 WP_001134469.1 NZ_OX030728:4582970-4583752 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVTSLTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Download         Length: 783 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0Z9M0


Antitoxin

Source ID Structure

References