296556

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4099940..4101275 Replicon chromosome
Accession NZ_OX030728
Organism Escherichia coli isolate 68

Toxin (Protein)


Gene name sanaT Uniprot ID V0YQY2
Locus tag LQ200_RS19720 Protein ID WP_000342498.1
Coordinates 4100328..4101275 (+) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID E0J2C6
Locus tag LQ200_RS19715 Protein ID WP_000152741.1
Coordinates 4099940..4100335 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ200_RS19685 (4095707) 4095707..4096660 + 954 WP_000290408.1 hypothetical protein -
LQ200_RS19690 (4096897) 4096897..4097715 + 819 WP_001046747.1 DUF932 domain-containing protein -
LQ200_RS19695 (4097745) 4097745..4098218 + 474 WP_001292743.1 DNA repair protein RadC -
LQ200_RS19700 (4098218) 4098218..4098553 + 336 WP_000939436.1 type IV toxin-antitoxin system YeeU family antitoxin -
LQ200_RS19705 (4098584) 4098584..4098925 + 342 WP_000691792.1 TA system toxin CbtA family protein -
LQ200_RS19710 (4099037) 4099037..4099870 + 834 WP_001192747.1 DUF4942 domain-containing protein -
LQ200_RS19715 (4099940) 4099940..4100335 + 396 WP_000152741.1 DUF6088 family protein Antitoxin
LQ200_RS19720 (4100328) 4100328..4101275 + 948 WP_000342498.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LQ200_RS19725 (4101313) 4101313..4101498 - 186 WP_000066585.1 hypothetical protein -
LQ200_RS19730 (4101597) 4101597..4101740 - 144 Protein_3856 HNH endonuclease -
LQ200_RS19735 (4101877) 4101877..4102527 + 651 WP_001037973.1 HNH endonuclease -
LQ200_RS19740 (4102535) 4102535..4103515 - 981 WP_000991420.1 sialate O-acetylesterase -
LQ200_RS19745 (4103580) 4103580..4104686 - 1107 WP_001328295.1 N-acetylneuraminate epimerase -
LQ200_RS19750 (4104706) 4104706..4105422 - 717 WP_001295734.1 N-acetylneuraminic acid outer membrane channel NanC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB / fimE / fimA / fimI / fimC 4088260..4110951 22691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-303)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 35616.84 Da        Isoelectric Point: 4.9737

>T296556 WP_000342498.1 NZ_OX030728:4100328-4101275 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEVYSRFRSLALAILNA

Download         Length: 948 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14619.93 Da        Isoelectric Point: 11.6915

>AT296556 WP_000152741.1 NZ_OX030728:4099940-4100335 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRELVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0YQY2

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4ZXD4

References