296553

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3975677..3976272 Replicon chromosome
Accession NZ_OX030728
Organism Escherichia coli isolate 68

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag LQ200_RS19140 Protein ID WP_000239581.1
Coordinates 3975922..3976272 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID V0YZQ7
Locus tag LQ200_RS19135 Protein ID WP_001223206.1
Coordinates 3975677..3975928 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ200_RS19125 (3971342) 3971342..3975121 + 3780 WP_000060869.1 autotransporter assembly complex protein TamB -
LQ200_RS19130 (3975124) 3975124..3975465 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LQ200_RS19135 (3975677) 3975677..3975928 + 252 WP_001223206.1 type II toxin-antitoxin system ChpS family antitoxin Antitoxin
LQ200_RS19140 (3975922) 3975922..3976272 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
LQ200_RS19145 (3976351) 3976351..3976881 - 531 WP_000055075.1 inorganic diphosphatase -
LQ200_RS19150 (3977191) 3977191..3978147 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LQ200_RS19155 (3978289) 3978289..3979791 + 1503 WP_001095668.1 sugar ABC transporter ATP-binding protein -
LQ200_RS19160 (3979805) 3979805..3980827 + 1023 WP_024176215.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T296553 WP_000239581.1 NZ_OX030728:3975922-3976272 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9303.62 Da        Isoelectric Point: 4.6509

>AT296553 WP_001223206.1 NZ_OX030728:3975677-3975928 [Escherichia coli]
MRITIKKWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB V0YZQ7

References