Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3879343..3879840 Replicon chromosome
Accession NZ_OX030728
Organism Escherichia coli isolate 68

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LQ200_RS18645 Protein ID WP_001173343.1
Coordinates 3879667..3879840 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag LQ200_RS18640 Protein ID WP_000398619.1
Coordinates 3879343..3879639 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ200_RS18620 (3876074) 3876074..3876793 - 720 WP_000611288.1 two-component system response regulator DcuR -
LQ200_RS18625 (3876790) 3876790..3878421 - 1632 WP_001216481.1 sensor histidine kinase -
LQ200_RS18630 (3878602) 3878602..3878832 + 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
LQ200_RS18635 (3878844) 3878844..3879116 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
LQ200_RS18640 (3879343) 3879343..3879639 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LQ200_RS18645 (3879667) 3879667..3879840 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LQ200_RS18650 (3879959) 3879959..3881476 - 1518 WP_000003806.1 lysine--tRNA ligase -
LQ200_RS18655 (3881713) 3881713..3883170 - 1458 WP_000856827.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T296552 WP_001173343.1 NZ_OX030728:3879667-3879840 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT296552 WP_000398619.1 NZ_OX030728:3879343-3879639 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References