Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2340089..2340743 Replicon chromosome
Accession NZ_OX030728
Organism Escherichia coli isolate 68

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag LQ200_RS11370 Protein ID WP_000244781.1
Coordinates 2340089..2340496 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LQ200_RS11375 Protein ID WP_000354046.1
Coordinates 2340477..2340743 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ200_RS11350 (2336046) 2336046..2337779 - 1734 WP_000813226.1 single-stranded-DNA-specific exonuclease RecJ -
LQ200_RS11355 (2337785) 2337785..2338495 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ200_RS11360 (2338520) 2338520..2339416 - 897 WP_000806652.1 site-specific tyrosine recombinase XerD -
LQ200_RS11365 (2339528) 2339528..2340049 + 522 WP_001055874.1 flavodoxin FldB -
LQ200_RS11370 (2340089) 2340089..2340496 - 408 WP_000244781.1 protein YgfX Toxin
LQ200_RS11375 (2340477) 2340477..2340743 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LQ200_RS11380 (2340986) 2340986..2341966 + 981 WP_000886086.1 tRNA-modifying protein YgfZ -
LQ200_RS11385 (2342043) 2342043..2342702 - 660 WP_000250269.1 hemolysin III family protein -
LQ200_RS11390 (2342866) 2342866..2343177 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
LQ200_RS11395 (2343222) 2343222..2344655 + 1434 WP_001559758.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T296549 WP_000244781.1 NZ_OX030728:c2340496-2340089 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT296549 WP_000354046.1 NZ_OX030728:c2340743-2340477 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References