Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 705351..706939 Replicon chromosome
Accession NZ_OX030728
Organism Escherichia coli isolate 68

Toxin (Protein)


Gene name hipA Uniprot ID V0Z3Q2
Locus tag LQ200_RS03485 Protein ID WP_001125418.1
Coordinates 705351..706673 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LQ200_RS03490 Protein ID WP_001327997.1
Coordinates 706673..706939 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ200_RS03445 (700385) 700385..700957 - 573 WP_000789912.1 NAD(P)H-dependent oxidoreductase -
LQ200_RS03450 (701108) 701108..701260 - 153 WP_001322417.1 amidohydrolase family protein -
LQ200_RS03455 (701250) 701250..701669 - 420 WP_001327999.1 amidohydrolase family protein -
LQ200_RS03460 (701629) 701629..701784 - 156 WP_001327998.1 hypothetical protein -
LQ200_RS03465 (701887) 701887..702834 - 948 WP_000854796.1 aldo/keto reductase -
LQ200_RS03470 (702908) 702908..703597 - 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
LQ200_RS03475 (703606) 703606..703914 - 309 WP_001221046.1 hypothetical protein -
LQ200_RS03480 (704053) 704053..704952 + 900 WP_001057776.1 LysR family transcriptional regulator -
LQ200_RS03485 (705351) 705351..706673 - 1323 WP_001125418.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
LQ200_RS03490 (706673) 706673..706939 - 267 WP_001327997.1 type II toxin-antitoxin system antitoxin HipB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49316.95 Da        Isoelectric Point: 8.5823

>T296542 WP_001125418.1 NZ_OX030728:c706673-705351 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9975.33 Da        Isoelectric Point: 6.2156

>AT296542 WP_001327997.1 NZ_OX030728:c706939-706673 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSGLAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0Z3Q2

Antitoxin

Source ID Structure

References