296541

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 604320..604958 Replicon chromosome
Accession NZ_OX030728
Organism Escherichia coli isolate 68

Toxin (Protein)


Gene name hicA Uniprot ID B7N4J4
Locus tag LQ200_RS03045 Protein ID WP_000813797.1
Coordinates 604320..604496 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LQ200_RS03050 Protein ID WP_001270286.1
Coordinates 604542..604958 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ200_RS03025 (599942) 599942..601114 - 1173 WP_001236217.1 BenE family transporter YdcO -
LQ200_RS03030 (601206) 601206..601742 + 537 WP_000429505.1 DNA-binding transcriptional regulator SutR -
LQ200_RS03035 (601815) 601815..603776 + 1962 WP_001445698.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LQ200_RS03040 (603868) 603868..604098 - 231 WP_000491976.1 YncJ family protein -
LQ200_RS03045 (604320) 604320..604496 + 177 WP_000813797.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LQ200_RS03050 (604542) 604542..604958 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LQ200_RS03055 (605037) 605037..606443 + 1407 WP_000760596.1 PLP-dependent aminotransferase family protein -
LQ200_RS03060 (606688) 606688..607833 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
LQ200_RS03065 (607851) 607851..608864 + 1014 WP_000220398.1 ABC transporter ATP-binding protein -
LQ200_RS03070 (608865) 608865..609806 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.76 Da        Isoelectric Point: 11.5666

>T296541 WP_000813797.1 NZ_OX030728:604320-604496 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT296541 WP_001270286.1 NZ_OX030728:604542-604958 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J715

Antitoxin

Source ID Structure

References