296530

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 25529..26172 Replicon plasmid P1
Accession NZ_OX030702
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag LQ128_RS24925 Protein ID WP_001044768.1
Coordinates 25529..25945 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID E9XUD3
Locus tag LQ128_RS24930 Protein ID WP_001261279.1
Coordinates 25942..26172 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ128_RS24905 (21844) 21844..22875 + 1032 Protein_21 IS3 family transposase -
LQ128_RS24910 (23429) 23429..23614 - 186 Protein_22 transposase domain-containing protein -
LQ128_RS24915 (23684) 23684..23827 + 144 Protein_23 transposase -
LQ128_RS24920 (24198) 24198..24806 - 609 WP_000515889.1 ProQ/FINO family protein -
LQ128_RS24925 (25529) 25529..25945 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ128_RS24930 (25942) 25942..26172 - 231 WP_001261279.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQ128_RS24935 (26777) 26777..27190 + 414 WP_001581782.1 hypothetical protein -
LQ128_RS24940 (27192) 27192..27977 + 786 WP_001581781.1 site-specific integrase -
LQ128_RS24945 (28561) 28561..29193 + 633 WP_000312331.1 ParA family protein -
LQ128_RS24950 (29193) 29193..29567 + 375 WP_000752652.1 hypothetical protein -
LQ128_RS24955 (29805) 29805..30779 + 975 WP_001217836.1 plasmid segregation protein ParM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B - 1..90741 90741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T296530 WP_001044768.1 NZ_OX030702:c25945-25529 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8761.90 Da        Isoelectric Point: 4.6310

>AT296530 WP_001261279.1 NZ_OX030702:c26172-25942 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDRIILRPVRPAWGSFAQLEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A3U0EQM4

References