296529

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1772..2319 Replicon plasmid P1
Accession NZ_OX030702
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LQ128_RS24810 Protein ID WP_244427497.1
Coordinates 2041..2319 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5JBQ7
Locus tag LQ128_RS24805 Protein ID WP_000079943.1
Coordinates 1772..2041 (+) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ128_RS24800 (1) 1..858 + 858 WP_000130646.1 incFII family plasmid replication initiator RepA -
LQ128_RS24805 (1772) 1772..2041 + 270 WP_000079943.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
LQ128_RS24810 (2041) 2041..2319 + 279 WP_244427497.1 type II toxin-antitoxin system toxin YacB Toxin
LQ128_RS24815 (2365) 2365..3213 + 849 WP_001058010.1 3'-5' exonuclease -
LQ128_RS24820 (3330) 3330..3614 + 285 Protein_4 hypothetical protein -
LQ128_RS24825 (3629) 3629..6634 - 3006 WP_001143775.1 Tn3-like element Tn3 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B - 1..90741 90741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10743.33 Da        Isoelectric Point: 7.3987

>T296529 WP_244427497.1 NZ_OX030702:2041-2319 [Escherichia coli]
MEIFWTMLASQDRKHIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp


Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10272.57 Da        Isoelectric Point: 7.2057

>AT296529 WP_000079943.1 NZ_OX030702:1772-2041 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLSHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A622US83

References