296523

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4111862..4112480 Replicon chromosome
Accession NZ_OX030701
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ128_RS19830 Protein ID WP_001291435.1
Coordinates 4111862..4112080 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ128_RS19835 Protein ID WP_000344800.1
Coordinates 4112106..4112480 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ128_RS19795 (4107149) 4107149..4107721 + 573 WP_000779831.1 YbaY family lipoprotein -
LQ128_RS19800 (4107752) 4107752..4108063 - 312 WP_000409908.1 MGMT family protein -
LQ128_RS19810 (4108442) 4108442..4108795 + 354 WP_000878135.1 DUF1428 family protein -
LQ128_RS19815 (4108837) 4108837..4110387 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ128_RS19820 (4110551) 4110551..4111021 - 471 WP_000136192.1 YlaC family protein -
LQ128_RS19825 (4111137) 4111137..4111688 - 552 WP_000102539.1 maltose O-acetyltransferase -
LQ128_RS19830 (4111862) 4111862..4112080 - 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ128_RS19835 (4112106) 4112106..4112480 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ128_RS19840 (4113026) 4113026..4116175 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
LQ128_RS19845 (4116198) 4116198..4117391 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T296523 WP_001291435.1 NZ_OX030701:c4112080-4111862 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT296523 WP_000344800.1 NZ_OX030701:c4112480-4112106 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References