Detailed information of TA system TA296522

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3925454..3927143
• Replicon: chromosome
• Accession: NZ_OX030701
• Organism: Escherichia coli isolate 131

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: LQ128_RS18950
• Protein ID: WP_000365807.1
• Coordinates: 3926223..3927143 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: LQ128_RS18945
• Protein ID: WP_001295795.1
• Coordinates: 3925454..3926236 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ128_RS18940 (3922072)	3922072..3925170	-	3099	WP_000673070.1	type I restriction endonuclease	-
LQ128_RS18945 (3925454)	3925454..3926236	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
LQ128_RS18950 (3926223)	3926223..3927143	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LQ128_RS18955 (3927308)	3927308..3928084	-	777	WP_000171155.1	site-specific integrase	-
LQ128_RS18960 (3928292)	3928292..3928627	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
LQ128_RS18965 (3928854)	3928854..3929012	-	159	Protein_3707	integrase	-
LQ128_RS18970 (3929061)	3929061..3929246	+	186	WP_000146240.1	hypothetical protein	-
LQ128_RS18975 (3929461)	3929461..3930075	+	615	WP_001019923.1	YagU family protein	-
LQ128_RS18980 (3930146)	3930146..3930312	+	167	Protein_3710	tail fiber assembly protein	-
LQ128_RS18985 (3930324)	3930324..3930653	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
LQ128_RS18990 (3930960)	3930960..3931670	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	3919204..3968613	49409

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T296522 WP_000365807.1 NZ_OX030701:3926223-3927143 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT296522 WP_001295795.1 NZ_OX030701:3925454-3926236 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0