296521

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3658241..3658761 Replicon chromosome
Accession NZ_OX030701
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name ccdB Uniprot ID A0A061KX66
Locus tag LQ128_RS17655 Protein ID WP_001160964.1
Coordinates 3658477..3658761 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag LQ128_RS17650 Protein ID WP_000125566.1
Coordinates 3658241..3658474 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ128_RS17625 (3653314) 3653314..3653601 + 288 WP_000203744.1 ferredoxin-like protein FixX -
LQ128_RS17630 (3653660) 3653660..3654991 + 1332 WP_001183209.1 MFS transporter -
LQ128_RS17635 (3655099) 3655099..3655629 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
LQ128_RS17640 (3655622) 3655622..3657484 + 1863 WP_000377106.1 glutathione-regulated potassium-efflux system protein KefC -
LQ128_RS17645 (3657676) 3657676..3658155 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
LQ128_RS17650 (3658241) 3658241..3658474 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LQ128_RS17655 (3658477) 3658477..3658761 + 285 WP_001160964.1 CcdB family protein Toxin
LQ128_RS17660 (3658788) 3658788..3659636 - 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
LQ128_RS17665 (3659643) 3659643..3660020 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
LQ128_RS17670 (3660023) 3660023..3660844 - 822 WP_001065365.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
LQ128_RS17675 (3660841) 3660841..3661830 - 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
LQ128_RS17680 (3661830) 3661830..3663116 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-93)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10692.54 Da        Isoelectric Point: 10.3030

>T296521 WP_001160964.1 NZ_OX030701:3658477-3658761 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK

Download         Length: 285 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT296521 WP_000125566.1 NZ_OX030701:3658241-3658474 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KX66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References