296518

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3322933..3323528 Replicon chromosome
Accession NZ_OX030701
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag LQ128_RS15965 Protein ID WP_000239579.1
Coordinates 3323178..3323528 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag LQ128_RS15960 Protein ID WP_001223208.1
Coordinates 3322933..3323184 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ128_RS15950 (3318598) 3318598..3322377 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
LQ128_RS15955 (3322380) 3322380..3322721 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LQ128_RS15960 (3322933) 3322933..3323184 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LQ128_RS15965 (3323178) 3323178..3323528 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
LQ128_RS15970 (3323608) 3323608..3324138 - 531 WP_000055075.1 inorganic diphosphatase -
LQ128_RS15975 (3324448) 3324448..3325404 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LQ128_RS15980 (3325544) 3325544..3327046 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
LQ128_RS15985 (3327060) 3327060..3328082 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T296518 WP_000239579.1 NZ_OX030701:3323178-3323528 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT296518 WP_001223208.1 NZ_OX030701:3322933-3323184 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References