Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2391829..2392629 Replicon chromosome
Accession NZ_OX030701
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag LQ128_RS11665 Protein ID WP_000342452.1
Coordinates 2391829..2392356 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag LQ128_RS11670 Protein ID WP_001277107.1
Coordinates 2392363..2392629 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ128_RS11640 (2386905) 2386905..2387672 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LQ128_RS11645 (2387669) 2387669..2388946 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
LQ128_RS11650 (2388943) 2388943..2389869 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LQ128_RS11655 (2389917) 2389917..2391026 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LQ128_RS11660 (2391449) 2391449..2391832 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
LQ128_RS11665 (2391829) 2391829..2392356 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
LQ128_RS11670 (2392363) 2392363..2392629 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
LQ128_RS11675 (2392778) 2392778..2393881 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
LQ128_RS11680 (2394152) 2394152..2395006 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
LQ128_RS11685 (2395251) 2395251..2396309 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
LQ128_RS11690 (2396302) 2396302..2396970 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T296515 WP_000342452.1 NZ_OX030701:c2392356-2391829 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT296515 WP_001277107.1 NZ_OX030701:c2392629-2392363 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References