Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4791675..4792485 Replicon chromosome
Accession NZ_OW970560
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag LQV17_RS23350 Protein ID WP_002887280.1
Coordinates 4791675..4792208 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag LQV17_RS23355 Protein ID WP_002887278.1
Coordinates 4792219..4792485 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV17_RS23345 (4790507) 4790507..4791628 + 1122 WP_009309849.1 cupin domain-containing protein -
LQV17_RS23350 (4791675) 4791675..4792208 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
LQV17_RS23355 (4792219) 4792219..4792485 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
LQV17_RS23360 (4792588) 4792588..4794021 - 1434 WP_023288193.1 Cu(+)/Ag(+) sensor histidine kinase -
LQV17_RS23365 (4794011) 4794011..4794694 - 684 WP_032105399.1 copper response regulator transcription factor CusR -
LQV17_RS23370 (4794867) 4794867..4796252 + 1386 WP_032431458.1 efflux transporter outer membrane subunit -
LQV17_RS23375 (4796270) 4796270..4796575 + 306 WP_032432083.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T296499 WP_002887280.1 NZ_OW970560:c4792208-4791675 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT296499 WP_002887278.1 NZ_OW970560:c4792485-4792219 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References