Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1640581..1641317 Replicon chromosome
Accession NZ_OW970560
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag LQV17_RS08150 Protein ID WP_032433360.1
Coordinates 1640835..1641317 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LQV17_RS08145 Protein ID WP_003026799.1
Coordinates 1640581..1640847 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV17_RS08120 (1636227) 1636227..1637366 + 1140 WP_032433368.1 mannitol dehydrogenase -
LQV17_RS08125 (1637395) 1637395..1638057 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
LQV17_RS08130 (1638038) 1638038..1639045 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
LQV17_RS08135 (1639063) 1639063..1639695 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
LQV17_RS08140 (1639705) 1639705..1640268 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
LQV17_RS08145 (1640581) 1640581..1640847 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LQV17_RS08150 (1640835) 1640835..1641317 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
LQV17_RS08155 (1641517) 1641517..1642920 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
LQV17_RS08160 (1642949) 1642949..1643581 - 633 WP_060591614.1 hypothetical protein -
LQV17_RS08165 (1643961) 1643961..1644560 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
LQV17_RS08170 (1644773) 1644773..1645717 - 945 WP_077254249.1 fimbrial protein -
LQV17_RS08175 (1645729) 1645729..1645989 - 261 WP_035588053.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1610804..1654392 43588
- flank IS/Tn - - 1641517..1642920 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T296492 WP_032433360.1 NZ_OW970560:1640835-1641317 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT296492 WP_003026799.1 NZ_OW970560:1640581-1640847 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References