Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1623890..1624533 Replicon chromosome
Accession NZ_OW970560
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag LQV17_RS08055 Protein ID WP_032433387.1
Coordinates 1624117..1624533 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag LQV17_RS08050 Protein ID WP_001261276.1
Coordinates 1623890..1624120 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV17_RS08035 (1618912) 1618912..1619999 + 1088 Protein_1570 transcriptional repressor PifC -
LQV17_RS08040 (1620002) 1620002..1622242 + 2241 WP_045326788.1 P-loop NTPase fold protein -
LQV17_RS08045 (1622770) 1622770..1623585 - 816 WP_032433388.1 hypothetical protein -
LQV17_RS08050 (1623890) 1623890..1624120 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQV17_RS08055 (1624117) 1624117..1624533 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV17_RS08060 (1624689) 1624689..1625669 + 981 WP_032433385.1 hypothetical protein -
LQV17_RS08065 (1625864) 1625864..1627435 - 1572 WP_032433383.1 AAA family ATPase -
LQV17_RS08070 (1627754) 1627754..1628002 + 249 WP_032433382.1 hypothetical protein -
LQV17_RS08075 (1628061) 1628061..1628579 + 519 WP_045326794.1 hypothetical protein -
LQV17_RS08080 (1628610) 1628610..1629101 + 492 WP_032433378.1 hypothetical protein -
LQV17_RS08085 (1629161) 1629161..1629364 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1610804..1654392 43588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T296491 WP_032433387.1 NZ_OW970560:1624117-1624533 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT296491 WP_001261276.1 NZ_OW970560:1623890-1624120 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References