Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 439983..440608 Replicon chromosome
Accession NZ_OW970560
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag LQV17_RS02020 Protein ID WP_002882817.1
Coordinates 440225..440608 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LQV17_RS02015 Protein ID WP_004150355.1
Coordinates 439983..440225 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV17_RS01990 (435974) 435974..436573 + 600 WP_004151865.1 glucose-1-phosphatase -
LQV17_RS01995 (436567) 436567..437427 + 861 WP_004146232.1 virulence factor BrkB family protein -
LQV17_RS02000 (437424) 437424..437861 + 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LQV17_RS02005 (437906) 437906..438847 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LQV17_RS02010 (438861) 438861..439778 - 918 WP_021466676.1 alpha/beta hydrolase -
LQV17_RS02015 (439983) 439983..440225 + 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LQV17_RS02020 (440225) 440225..440608 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV17_RS02025 (440782) 440782..441711 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LQV17_RS02030 (441708) 441708..442343 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LQV17_RS02035 (442340) 442340..443242 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T296487 WP_002882817.1 NZ_OW970560:440225-440608 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT296487 WP_004150355.1 NZ_OW970560:439983-440225 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References