Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 116293..116816 Replicon plasmid P1
Accession NZ_OW970554
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name ccdB Uniprot ID V5RNQ6
Locus tag LQV20_RS26590 Protein ID WP_015632464.1
Coordinates 116293..116598 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V5RQR8
Locus tag LQV20_RS26595 Protein ID WP_015632465.1
Coordinates 116598..116816 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV20_RS26545 (AI2768V1_5037) 111323..111751 - 429 WP_015632456.1 plasmid partitioning/stability family protein -
LQV20_RS26550 (AI2768V1_5038) 111744..112724 - 981 WP_015632457.1 plasmid segregation protein ParM -
LQV20_RS26555 (AI2768V1_5039) 113085..113267 + 183 WP_015632458.1 type II toxin-antitoxin system HicA family toxin -
LQV20_RS26560 (AI2768V1_5040) 113293..113736 + 444 WP_015632459.1 type II toxin-antitoxin system HicB family antitoxin -
LQV20_RS26565 113942..114064 - 123 Protein_121 transcriptional regulator -
LQV20_RS26570 (AI2768V1_5042) 114078..114305 - 228 WP_016162072.1 hypothetical protein -
LQV20_RS26575 114537..114992 + 456 WP_015632461.1 helix-turn-helix domain-containing protein -
LQV20_RS26580 115244..115339 - 96 Protein_124 IS1 family transposase -
LQV20_RS26585 (AI2768V1_5045) 115804..116181 - 378 WP_016162069.1 hypothetical protein -
LQV20_RS26590 (AI2768V1_5046) 116293..116598 - 306 WP_015632464.1 type II toxin-antitoxin system toxin CcdB Toxin
LQV20_RS26595 (AI2768V1_5047) 116598..116816 - 219 WP_015632465.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
LQV20_RS26600 (AI2768V1_5048) 117002..118027 + 1026 WP_015632466.1 IS110 family transposase -
LQV20_RS26605 (AI2768V1_REPA000000032) 118322..118807 + 486 Protein_129 IS5 family transposase -
LQV20_RS26610 (AI2768V1_5049) 118971..119402 + 432 WP_015632467.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
LQV20_RS26615 (AI2768V1_5050) 119402..120673 + 1272 WP_016162068.1 Y-family DNA polymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid rmtF / ARR-3 - 1..121066 121066


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11361.90 Da        Isoelectric Point: 5.5252

>T296483 WP_015632464.1 NZ_OW970554:c116598-116293 [Klebsiella pneumoniae]
MQFTVYEYTRESHYRLFVDVQSDIVETPGRRIVIPLLESHHLSEKVNQQLFPVVSVNGKEYRAVTSELSGVSVSVIGDAV
ADLSHEANAIKNALNLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8194.13 Da        Isoelectric Point: 6.2224

>AT296483 WP_015632465.1 NZ_OW970554:c116816-116598 [Klebsiella pneumoniae]
MKHRASVTVDKEHYLELLAAGVNISGLVNEAIGREARRIQAERWKAENREGMEEVANFIAQHGSFADENRSW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C0ND19

Antitoxin

Source ID Structure
AlphaFold DB A0A6C0L1T7

References