Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4770406..4770922 Replicon chromosome
Accession NZ_OW970553
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LQV20_RS23250 Protein ID WP_009486548.1
Coordinates 4770406..4770690 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LQV20_RS23255 Protein ID WP_002886901.1
Coordinates 4770680..4770922 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV20_RS23225 (4765823) 4765823..4766086 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LQV20_RS23230 (4766216) 4766216..4766389 + 174 WP_032433782.1 hypothetical protein -
LQV20_RS23235 (4766392) 4766392..4767135 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LQV20_RS23240 (4767492) 4767492..4769630 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LQV20_RS23245 (4769938) 4769938..4770402 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQV20_RS23250 (4770406) 4770406..4770690 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQV20_RS23255 (4770680) 4770680..4770922 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQV20_RS23260 (4771000) 4771000..4772910 - 1911 WP_009486549.1 PRD domain-containing protein -
LQV20_RS23265 (4772933) 4772933..4774087 - 1155 WP_002886900.1 lactonase family protein -
LQV20_RS23270 (4774154) 4774154..4774894 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T296480 WP_009486548.1 NZ_OW970553:c4770690-4770406 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T296480 NZ_OW970553:c4770690-4770406 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT296480 WP_002886901.1 NZ_OW970553:c4770922-4770680 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT296480 NZ_OW970553:c4770922-4770680 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References