Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1495747..1496390 Replicon chromosome
Accession NZ_OW970553
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag LQV20_RS07435 Protein ID WP_032433387.1
Coordinates 1495974..1496390 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag LQV20_RS07430 Protein ID WP_001261276.1
Coordinates 1495747..1495977 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV20_RS07415 (1490769) 1490769..1491856 + 1088 Protein_1451 transcriptional repressor PifC -
LQV20_RS07420 (1491859) 1491859..1494099 + 2241 WP_045326788.1 P-loop NTPase fold protein -
LQV20_RS07425 (1494627) 1494627..1495442 - 816 WP_032433388.1 hypothetical protein -
LQV20_RS07430 (1495747) 1495747..1495977 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQV20_RS07435 (1495974) 1495974..1496390 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV20_RS07440 (1496546) 1496546..1497526 + 981 WP_032433385.1 hypothetical protein -
LQV20_RS07445 (1497721) 1497721..1499292 - 1572 WP_032433383.1 AAA family ATPase -
LQV20_RS07450 (1499611) 1499611..1499859 + 249 WP_032433382.1 hypothetical protein -
LQV20_RS07455 (1499918) 1499918..1500436 + 519 WP_045326794.1 hypothetical protein -
LQV20_RS07460 (1500467) 1500467..1500958 + 492 WP_032433378.1 hypothetical protein -
LQV20_RS07465 (1501018) 1501018..1501221 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1482661..1523966 41305


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T296471 WP_032433387.1 NZ_OW970553:1495974-1496390 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT296471 WP_001261276.1 NZ_OW970553:1495747-1495977 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References