Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5232141..5232766 Replicon chromosome
Accession NZ_OW970540
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag LQV19_RS25500 Protein ID WP_002882817.1
Coordinates 5232141..5232524 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LQV19_RS25505 Protein ID WP_004150355.1
Coordinates 5232524..5232766 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV19_RS25485 (5229507) 5229507..5230409 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LQV19_RS25490 (5230406) 5230406..5231041 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LQV19_RS25495 (5231038) 5231038..5231967 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LQV19_RS25500 (5232141) 5232141..5232524 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV19_RS25505 (5232524) 5232524..5232766 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LQV19_RS25510 (5232971) 5232971..5233888 + 918 WP_021466676.1 alpha/beta hydrolase -
LQV19_RS25515 (5233902) 5233902..5234843 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LQV19_RS25520 (5234888) 5234888..5235325 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LQV19_RS25525 (5235322) 5235322..5236182 - 861 WP_004146232.1 virulence factor BrkB family protein -
LQV19_RS25530 (5236176) 5236176..5236775 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T296465 WP_002882817.1 NZ_OW970540:c5232524-5232141 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT296465 WP_004150355.1 NZ_OW970540:c5232766-5232524 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References