Detailed information of TA system TA296464

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4919858..4921539
• Replicon: chromosome
• Accession: NZ_OW970540
• Organism: Klebsiella pneumoniae isolate 147

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: LQV19_RS24040
• Protein ID: WP_015959269.1
• Coordinates: 4919858..4920733 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LQV19_RS24045
• Protein ID: WP_004177809.1
• Coordinates: 4920781..4921539 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQV19_RS24020 (4915164)	4915164..4916684	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LQV19_RS24025 (4916681)	4916681..4917679	+	999	WP_002885172.1	ribose ABC transporter permease	-
LQV19_RS24030 (4917710)	4917710..4918651	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LQV19_RS24035 (4918726)	4918726..4919733	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
LQV19_RS24040 (4919858)	4919858..4920733	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LQV19_RS24045 (4920781)	4920781..4921539	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LQV19_RS24050 (4921625)	4921625..4922353	-	729	WP_032413197.1	response regulator transcription factor	-
LQV19_RS24055 (4922626)	4922626..4924773	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
LQV19_RS24060 (4924932)	4924932..4926295	+	1364	WP_085955203.1	IS3-like element ISKpn1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T296464 WP_015959269.1 NZ_OW970540:c4920733-4919858 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT296464 WP_004177809.1 NZ_OW970540:c4921539-4920781 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05