Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1486564..1487207 Replicon chromosome
Accession NZ_OW970540
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag LQV19_RS07400 Protein ID WP_032433387.1
Coordinates 1486791..1487207 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag LQV19_RS07395 Protein ID WP_001261276.1
Coordinates 1486564..1486794 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV19_RS07380 (1481586) 1481586..1482673 + 1088 Protein_1444 transcriptional repressor PifC -
LQV19_RS07385 (1482676) 1482676..1484916 + 2241 WP_045326788.1 P-loop NTPase fold protein -
LQV19_RS07390 (1485444) 1485444..1486259 - 816 WP_032433388.1 hypothetical protein -
LQV19_RS07395 (1486564) 1486564..1486794 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQV19_RS07400 (1486791) 1486791..1487207 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV19_RS07405 (1487363) 1487363..1488343 + 981 WP_032433385.1 hypothetical protein -
LQV19_RS07410 (1488538) 1488538..1490109 - 1572 WP_032433383.1 AAA family ATPase -
LQV19_RS07415 (1490428) 1490428..1490676 + 249 WP_032433382.1 hypothetical protein -
LQV19_RS07420 (1490735) 1490735..1491253 + 519 WP_045326794.1 hypothetical protein -
LQV19_RS07425 (1491284) 1491284..1491775 + 492 WP_032433378.1 hypothetical protein -
LQV19_RS07430 (1491835) 1491835..1492038 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1473478..1517066 43588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T296454 WP_032433387.1 NZ_OW970540:1486791-1487207 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT296454 WP_001261276.1 NZ_OW970540:1486564-1486794 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References