Detailed information of TA system TA296447

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4918274..4919955
• Replicon: chromosome
• Accession: NZ_OW970530
• Organism: Klebsiella pneumoniae isolate 147

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: LQV07_RS24035
• Protein ID: WP_015959269.1
• Coordinates: 4918274..4919149 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LQV07_RS24040
• Protein ID: WP_004177809.1
• Coordinates: 4919197..4919955 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQV07_RS24015 (4913580)	4913580..4915100	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LQV07_RS24020 (4915097)	4915097..4916095	+	999	WP_002885172.1	ribose ABC transporter permease	-
LQV07_RS24025 (4916126)	4916126..4917067	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LQV07_RS24030 (4917142)	4917142..4918149	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
LQV07_RS24035 (4918274)	4918274..4919149	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LQV07_RS24040 (4919197)	4919197..4919955	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LQV07_RS24045 (4920041)	4920041..4920769	-	729	WP_032413197.1	response regulator transcription factor	-
LQV07_RS24050 (4921042)	4921042..4923189	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
LQV07_RS24055 (4923348)	4923348..4924711	+	1364	WP_085955203.1	IS3-like element ISKpn1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T296447 WP_015959269.1 NZ_OW970530:c4919149-4918274 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT296447 WP_004177809.1 NZ_OW970530:c4919955-4919197 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05