Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2755455..2757043 Replicon chromosome
Accession NZ_OW970530
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag LQV07_RS13595 Protein ID WP_002904792.1
Coordinates 2755455..2756777 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LQV07_RS13600 Protein ID WP_002904790.1
Coordinates 2756777..2757043 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV07_RS13580 (2750511) 2750511..2753012 + 2502 WP_142478220.1 fimbria/pilus outer membrane usher protein -
LQV07_RS13585 (2753000) 2753000..2754004 + 1005 WP_032433097.1 fimbrial protein -
LQV07_RS13590 (2754146) 2754146..2755438 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LQV07_RS13595 (2755455) 2755455..2756777 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
LQV07_RS13600 (2756777) 2756777..2757043 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LQV07_RS13605 (2757429) 2757429..2757755 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LQV07_RS13610 (2757752) 2757752..2758252 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LQV07_RS13615 (2758230) 2758230..2759609 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
LQV07_RS13620 (2759955) 2759955..2761109 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LQV07_RS13625 (2761090) 2761090..2762013 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T296443 WP_002904792.1 NZ_OW970530:c2756777-2755455 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT296443 WP_002904790.1 NZ_OW970530:c2757043-2756777 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References